In-vitro Validation of Coronary Physiology Algorithms

The Challenge

Validating coronary physiology algorithms often requires access to patients and cath-lab time, while clinical variability makes it difficult to isolate the influence of individual physiological parameters.

Our Approach

Pulso Technology provides a controlled in-vitro framework in which healthy and pathological coronary scenarios can be reproduced repeatedly.

The platform allows development teams to vary key parameters such as:

• microvascular resistance;

• coronary flow and pressure;

• stenosis severity;

• flow obstruction;

• vascular dysfunction.

By adjusting these parameters independently, engineers and cardiologists can assess their specific impact on algorithm performance.

The Impact

Pulso helps reduce reliance on early patient-based testing, shorten validation cycles, improve reproducibility, and identify the operating conditions in which an algorithm performs best.

This structured framework supports both technical development and clinical interpretation, enabling teams to make more efficient use of subsequent cath-lab and clinical validation phases.

Key Benefits

• Repeatable healthy and pathological scenarios

• Independent control of physiological parameters

• Faster algorithm testing and refinement

• Reduced variability compared with early clinical testing

• Stronger collaboration between engineering and clinical teams

• Better preparation for subsequent clinical validation